Qifuyin against CCL11-Induced cognitive impairment by inhibiting microglial senescence via CCR3 signaling.

Sheng Tian, Tianyuan Ye, Chao Tian, Yipeng Zhang, He Li, Hui Shen, Youhua Xu, Xiaorui Cheng

Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, 999078, P.R. China.Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, 999078, P.R. China. · pubmed

Paper

Abstract

The chemokine CCL11 is negatively correlated with cognitive function and is able to cause dysfunctions of synaptic plasticity. This research investigate whether CCL11 induce microglia senescence to damage synaptic plasticity and the protective role of Qifuyin.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that Qifuyin can inhibit microglial senescence induced by CCL11, thereby protecting synaptic plasticity. This research addresses the role of microglial senescence in cognitive impairment, which is a significant aspect of aging and age-related cognitive decline.

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