Early Vascular Aging Determined by 3-Dimensional Aortic Geometry: Genetic Determinants and Clinical Consequences.

Cameron Beeche, Bingxin Zhao, Hamed Tavolinejad, Bianca Pourmussa, Joonghyun Kim, Jeffrey Duda, James Gee, Walter R Witschey, Julio A Chirinos

Department of Bioengineering, University of Pennsylvania, Philadelphia. (C.B., J.K.).Department of Bioengineering, University of Pennsylvania, Philadelphia. (C.B., J.K.). · pubmed

Paper

Abstract

Vascular aging is an important phenotype characterized by structural and geometric remodeling. Some individuals exhibit supernormal vascular aging, associated with improved cardiovascular outcomes; others experience early vascular aging, linked to adverse cardiovascular outcomes. The aorta is the artery that exhibits the most prominent age-related changes; however, the biological mechanisms underlying aortic aging, its genetic architecture, and its relationship with cardiovascular structure, function, and disease states remain poorly understood.

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Research summary

The paper claims that early vascular aging is influenced by 3-dimensional aortic geometry and genetic factors, which have clinical consequences for cardiovascular health. This research is relevant as it explores the biological mechanisms of vascular aging, which is a key aspect of the aging process and its impact on longevity and age-related diseases.

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