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RESEARCH PAPER / 2025-07-17

Along the Trajectory to Understanding Cellular Aging: More Lessons from Yeast.

Kiyan Shabestary, Reinhard Dechant, Daniel E Gottschling

Calico Life Sciences LLC, South San Francisco, California, USA; email: [email protected] Life Sciences LLC, South San Francisco, California, USA; email: [email protected]. · pubmed

Abstract

Aging is a universal biological phenomenon that affects all biological systems. It is characterized by the inability to remain in a balanced physiological state, leading to a functional decline of the organism and, in metazoa, an increased risk of age-related diseases. Identifying causal drivers of aging is a major challenge at the cellular level, but in the model organism

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Research summary

The paper explores the cellular mechanisms of aging using yeast as a model organism. This research is relevant as it aims to identify causal drivers of aging, which is fundamental to understanding and potentially mitigating the aging process.

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