p38 mitogen-activated protein kinase drives senescence in CD4

Luis González-Osuna, Sandra Yasuyo Fukada, María Paz Hernández-Cáceres, Patricia Luz-Crawford, Cristian Cortez, Carolina Rojas, Paola Carvajal, Alfredo Sierra-Cristancho, Rolando Vernal

Periodontal Biology Laboratory, Faculty of Dentistry, Universidad de Chile, Santiago, Chile. [email protected] Biology Laboratory, Faculty of Dentistry, Universidad de Chile, Santiago, Chile. [email protected]. · pubmed

Paper

Abstract

In several diseases, senescent T lymphocytes increase in number and release a senescence-associated secretory phenotype (SASP) with inflammatory and osteoclastogenic potential, favoring inflammation and bone loss. It is well known that the activation of p38 mitogen-activated protein kinase (p38 MAPK) orchestrates senescence in CD8

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Research summary

The paper claims that p38 mitogen-activated protein kinase drives senescence in CD4 T lymphocytes. The study is relevant as it explores the mechanisms of cellular senescence, which is a key factor in aging and age-related diseases, potentially offering insights into interventions that could mitigate these processes.

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