Extracellular vesicles from antler blastema progenitor cells reverse bone loss and mitigate aging-related phenotypes in mice and macaques.

Yiming Hao, Beibei Yu, Mingze Qin, Tao Qin, Jianhong Wang, Yitao Wei, Chengxiang Zhao, Yaowen Xing, Yuan Yuan, Tingfeng Xue, Borui Xue, Yali Zhang, Hongdi Huang, Xiaomei Yu, Yunchao Ji, Minghao Qiu, Yufang Zhou, Bing Xia, Teng Ma, Shengyou Li, Haining Wu, Xue Gao, Yujie Yang, Lingli Guo, Yongfeng Zhang, Zhenguo Wang, Huiling Sun, Xueli Gao, Zujian Huang, Longbao Lv, Dongdong Wu, Zhipeng Li, Yonggang Yao, Wen Wang, Zhuojing Luo, Qiang Qiu, Jinghui Huang

Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, China.Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, China. · pubmed

Paper

Abstract

Antler blastema progenitor cells (ABPCs) are a distinct population of skeletal mesenchymal stem cells found in regenerating deer antlers, with strong stemness and renewal capacity in vitro. Stem cell-derived extracellular vesicles (EVs) are emerging as potential therapeutic candidates that can mediate donor cells' beneficial effects. Here, we tested the effects of ABPC-derived EVs (EVs

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Research summary

ABPC-derived extracellular vesicles can reverse bone loss and mitigate aging-related phenotypes in mice and macaques. The study addresses potential mechanisms for rejuvenation and regeneration, which are central to longevity research.

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