Single-cell and spatial transcriptomics map senescent vascular cells in arterial remodeling during atherosclerosis in mice.

Krystyna Mazan-Mamczarz, Dimitrios Tsitsipatis, Bennett G Childs, Angelica E Carr, Carla Rocha Dos Santos, Carlos Anerillas, Brigette Romero, Jordan M Gregg, Charnae' Henry-Smith, Ada N Okereke, Marc Michel, Rachel Munk, Jennifer L Martindale, Yulan Piao, Jinshui Fan, Maria O Hernandez, Noemi Kedei, Michael L Viacheslavov, Madeline M F Wong, Olga V Fedorova, Mona Batish, Supriyo De, Darren J Baker, Myriam Gorospe, Allison B Herman

Laboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA. · pubmed

Paper

Abstract

Growing evidence suggests that the induction of cellular senescence in vascular cells is causally linked to the etiology of cardiovascular diseases. To investigate systematically the heterogeneity of senescent vascular cells in atherosclerosis, we used a high-fat diet and PCSK9 overexpression to induce atherosclerosis in a senescence reporter mouse model (p16-tdTomato

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Research summary

The paper claims to systematically investigate the heterogeneity of senescent vascular cells in atherosclerosis. This research is relevant as it addresses cellular senescence, a key mechanism implicated in aging and age-related diseases, potentially contributing to understanding and mitigating the root causes of cardiovascular aging.

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