The exposome of healthy and accelerated aging across 40 countries.

Hernan Hernandez, Hernando Santamaria-Garcia, Sebastian Moguilner, Francesca R Farina, Agustina Legaz, Pavel Prado, Jhosmary Cuadros, Liset Gonzalez, Raul Gonzalez-Gomez, Joaquín Migeot, Carlos Coronel-Oliveros, Enzo Tagliazucchi, Marcelo Adrián Maito, María E Godoy, Josephine Cruzat, Ahmed Shaheen, Temitope Farombi, Daniel Salazar, Lucas Uglione Da Ros, Wyllians V Borelli, Eduardo R Zimmer, Alfred K Njamnshi, Swati Bajpai, A B Dey, Cyprian Mostert, Zul Merali, Mohamed Salama, Sara A Moustafa, Sol Fittipaldi, Florencia Altschuler, Vicente Medel, David Huepe, Kristine Yaffe, Chinedu Momoh, Harris A Eyre, Pawel Swieboda, Brian Lawlor, J Jaime Miranda, Claudia Duran-Aniotz, Sandra Baez, Agustin Ibanez

Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile.Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile. · pubmed

Paper

Abstract

Protective and risk factors can drive healthy or accelerated aging, with distinct environments modulating their effects. The impact of the exposome-the combined physical and social exposures experienced throughout life-on accelerated aging remains unknown. We assessed delayed and accelerated aging in 161,981 participants from 40 countries (45.09% female; mean age, 67.06; s.d., 9.85) by measuring biobehavioral age gaps (BBAGs), defined as the difference between estimated age from protective and risk factors and chronological age, in cross-sectional and longitudinal designs. BBAGs predicted chronological age, followed by regional and exposomal factor analyses, linked to accelerated aging. Europe led in healthy aging, while Egypt and South Africa showed the greatest acceleration; Asia and Latin America fell in between (Cliff's delta (δd) = 0.15-0.52; all P < 0.0001). Accelerated aging was more evident in eastern and southern Europe; globally, it was also associated with lower income (δd = 0.48-0.56, P < 1 × 10

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Research summary

The paper claims that the exposome influences biobehavioral age gaps, which can predict accelerated aging across diverse populations. This research is relevant as it explores environmental factors affecting aging, potentially addressing root causes of accelerated aging rather than merely treating symptoms.

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