Epigenetic regulation of intracellular branched-chain amino acid homeostasis maintains a normal lifespan.

Sejung Park, Yan Liu, Suji Lim, Hong-Yeoul Ryu, Seong Hoon Ahn

Department of Medicinal and Life Science, College of Science and Convergence Technology, Hanyang University, Ansan, Gyeonggi-do 15588, Republic of Korea.Department of Medicinal and Life Science, College of Science and Convergence Technology, Hanyang University, Ansan, Gyeonggi-do 15588, Republic of Korea. · pubmed

Paper

Abstract

Cells experience a progressive decline in function and lifespan, accompanied by epigenetic changes. Here, we show that intracellular BCAA (icBCAA) homeostasis is regulated by histone H3K4 and H3K121 in budding yeast. Using a comprehensive H3/H4 mutant library, we identified residues essential for lifespan maintenance linked to BCAA metabolism. Among these, H3K4A/R and H3K121A mutations led to significant transcriptional changes in genes involved in BCAA biosynthesis and catabolism, accompanied by abnormally elevated icBCAA levels. Consistent with the upregulation of

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Research summary

The paper claims that epigenetic regulation of intracellular branched-chain amino acid homeostasis is crucial for maintaining normal lifespan. This research addresses the underlying mechanisms of aging by exploring how epigenetic factors influence metabolic processes related to lifespan, which is directly relevant to longevity studies.

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