Targeting phospholipase PLAG-15 promotes healthy aging in

Sanne van der Rijt, Marte Molenaars, Rashmi Kamble, Weisha Li, Bauke V Schomakers, Adrie D Dane, Simone W Denis, Michel van Weeghel, Frédéric M Vaz, Alessandra Tammaro, Georges E Janssens, Arwen W Gao, Riekelt H Houtkooper

Laboratory Genetic Metabolic Diseases, Department of Laboratory Medicine, Amsterdam UMC Location University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands.Laboratory Genetic Metabolic Diseases, Department of Laboratory Medicine, Amsterdam UMC Location University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands. · pubmed

Paper

Abstract

Complex lipid metabolism plays a crucial role in regulating aging. We recently discovered that the phospholipid bis(monoacylglycero)phosphate (BMP) increases in aged human muscles and many mouse tissues. The phospholipase PLA2G15 is reportedly involved in BMP synthesis, however, its specific role in aging remains unknown. To elucidate the role of PLA2G15 in aging, we used

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Research summary

Targeting phospholipase PLA2G15 may enhance healthy aging by influencing lipid metabolism. The study addresses a specific biochemical pathway related to aging, which is crucial for understanding and potentially mitigating the root causes of aging.

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