Blood-detected mitochondrial biomarker NSUN4: a potential indicator of ovarian aging.

Jianheng Hao, Liying Liu, Boya Chang, Yuemeng Zhao, Yuanyuan Lai, Chunhui Tian, Huichao Xu, Haijun Wang, Laixi Ji, Jie Yang

The Second Clinical College, Shanxi University of Chinese Medicine, Jinzhong 030619, China; College of acupuncture and massage, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.The Second Clinical College, Shanxi University of Chinese Medicine, Jinzhong 030619, China; College of acupuncture and massage, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China. · pubmed

Paper

Abstract

Mitochondrial dysfunction is a key hallmark of aging, and blood-based biomarkers related to mitochondrial genes provide an effective means to assess ovarian aging progression. In this study, we aimed to explore the role of mitochondrial dysfunction-related genetic variations in determining the natural age at menopause (ANM) by applying both Mendelian randomization (MR) and summary data-based Mendelian randomization (SMR) approaches, complemented by experimental validation in animal models.

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Research summary

The paper claims that mitochondrial biomarker NSUN4 can serve as an indicator of ovarian aging and natural age at menopause. This research is relevant as it explores mitochondrial dysfunction, a key aspect of aging, and its potential role in understanding ovarian aging, which could contribute to broader insights into the aging process.

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