Dietary Nucleotides Mitigate Age-Related Hepatic Lipid Dysregulation and Fibrosis.

Xiaoyu Guo, Chan Wei, Rui Liu, Xiujuan Wang, Xin Wu, Yong Li, Meihong Xu

Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China.Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China. · pubmed

Paper

Abstract

The aging process is often accompanied by hepatic metabolic dysregulation and related complications, including lipid accumulation and fibrosis. Nutritional interventions are crucial for maintaining metabolic health. This study explored the effects of exogenous nucleotides (NTs) on liver health in aged SAMP8 mice over 9 months. Results demonstrated dietary NTs effectively improved liver pathology, increased body mass, enhanced antioxidant capacity, reduced lipid accumulation, downregulated lipid synthesis genes, and lowered fibrosis-related markers. Mechanistically, NTs downregulated purine biosynthesis, modulating lipid metabolism-related transcription factors to reduce lipid accumulation. Additionally, NTs enhanced the efficiency of glycolysis and increased ATP synthesis. Thus, NTs exhibited substantial effects in regulating energy metabolism, suppressing lipid synthesis, and combating fibrosis. However, the effects displayed a nonlinear dose-dependent relationship, and the precise impact of NT dosage on health remains challenging. This study advances our understanding of NTs' role in aging and metabolic dysregulation.

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Research summary

Dietary nucleotides improve liver health in aged mice by mitigating lipid dysregulation and fibrosis. The study addresses metabolic dysregulation associated with aging, suggesting a potential nutritional intervention to combat age-related liver issues, which is relevant to longevity research.

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