Skeletal Muscle-Specific Deletion of E3 Ligase Asb2 Enhances Muscle Mass and Strength.

Hye Rim Jang, Shi-Young Park, Yeonmi Lee, Dongjin Lee, Jongjun Lee, Yoonil Cho, Cheol Soo Choi, Hui-Young Lee

Laboratory of Mitochondria and Metabolic Diseases, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Republic of Korea.Laboratory of Mitochondria and Metabolic Diseases, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Republic of Korea. · pubmed

Paper

Abstract

Maintaining skeletal muscle mass and strength is crucial to prevent sarcopenia during healthy ageing. Ankyrin repeat and suppressor of cytokine signalling box protein 2 (Asb2), an E3 ligase, has been implicated in regulating muscle mass; however, its roles on muscle strength remain unclear, with mixed findings from previous studies. Overexpression of Asb2 decreases muscle mass, whereas its knockdown delays myoblast differentiation and reduces contractile proteins. Given these contradictory findings, we aimed to clarify the role of Asb2 in muscle mass and strength using a skeletal muscle-specific Asb2 knockout (Asb2 MKO) mouse model. Additionally, we investigate the long-term effects of Asb2 on aged muscle, underlying mechanisms on muscle regulation and metabolic effects of Asb2 MKO mice to better understand its role in muscle function and age-related metabolic diseases.

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Research summary

The paper claims that skeletal muscle-specific deletion of E3 ligase Asb2 enhances muscle mass and strength. This research is relevant as it addresses the mechanisms underlying muscle mass and strength, which are critical factors in combating sarcopenia and promoting healthy aging.

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