Antigen specificity shapes distinct aging trajectories of memory CD8⁺ T cells.

Ines Sturmlechner, Abhinav Jain, Bin Hu, Rohit R Jadhav, Wenqiang Cao, Hirohisa Okuyama, Lu Tian, Cornelia M Weyand, Jörg J Goronzy

Department of Immunology, Mayo Clinic, Rochester, MN, USA. [email protected]. · pubmed

Paper

Abstract

Memory T cells are a highly heterogeneous collection of antigen-experienced cells that undergo dynamic adaptations upon antigen re-encounter and environmental signals. This heterogeneity hinders studies on memory T cell durability and age-related dysfunction. Using chronic Epstein-Barr virus (EBV) infection and barcode-enabled antigen tracing, we assess the influence of age on memory states at the level of single antigen-specific CD8

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Research summary

The paper claims that antigen specificity influences the aging trajectories of memory CD8⁺ T cells. This research is relevant as it explores the mechanisms underlying immune aging, which is a critical aspect of longevity and age-related dysfunction.

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