Neuroimmunology in ageing and longevity: a special collection issue of Biogerontology.

Gurcharan Kaur, Tamas Fulop, Arpita Konar, Jaspreet Singh

Department of Biotechnology, Guru Nanak Dev University, Amritsar, India. [email protected] of Biotechnology, Guru Nanak Dev University, Amritsar, India. [email protected]. · pubmed

Paper

Abstract

Ageing is associated with neuroimmune shifts from a resting to a hyperactive and inflammatory state, termed 'Neuroinflammageing', attributed to microglial priming, hyperactive astrocytes, cytokine and chemokine release, blood brain barrier leakage, and infiltration of peripheral immune cells. This special issue of Biogerontology on 'Neuroimmunology in Ageing and Longevity' brings together 11 reviews and original research papers dealing with the complex cross-talk between CNS and peripheral immune cells and molecules in the context of ageing. The articles compiled under this issue further address how understanding neuroimmune pathways may help to identify targets to design interventional regimens for healthy brain ageing and longevity.

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Research summary

Understanding neuroimmune pathways may help identify targets for interventions aimed at promoting healthy brain ageing and longevity. The paper addresses the underlying mechanisms of neuroinflammation in ageing, which is crucial for developing strategies to mitigate age-related decline and enhance longevity.

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