Protective Effects of Cedrol on Aging-Induced Cognitive Impairment in Rats.

Fatemeh Ghorbani, Mohammad Amin Forqani, Mahmoud Hosseini, Fatemeh Forouzanfar

Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. · pubmed

Paper

Abstract

Aging is a gradual alteration in cells and tissues' homeostasis mechanisms. Oxidative stress is an important contributor to aging. This study investigated the effect of cedrol a natural sesquiterpene on rats' memory and oxidative stress markers including malondialdehyde (MDA) and total thiol levels in the hippocampus, cortex, liver, heart, and kidneys of rats and their liver enzymes.

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Research summary

Cedrol may protect against aging-induced cognitive impairment by reducing oxidative stress markers in rats. The study addresses oxidative stress, a key factor in aging, and explores a potential intervention that could contribute to understanding mechanisms of cognitive decline associated with aging.

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