Aging disrupts hepatocyte zonation homeostasis in mice and humans.

Saloni Sinha, Qazi Ali, Tuo Zhang, Duc Huy T-Nguyen, Silvia Hanna, Jason Sethiadi, Erika Hissong, Robert E Schwartz

Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, New York, USA.Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, New York, USA. · pubmed

Paper

Abstract

Aging-induced degenerative changes in the liver are not inherently pathologic but pose an increased risk for liver diseases. However, the molecular mechanisms underlying aging-induced hepatic dyshomeostasis remain incompletely characterized. Here, we investigate how aging alters liver architecture, cellular communication, and hepatocyte zonation.

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Research summary

Aging disrupts hepatocyte zonation homeostasis in the liver. The paper addresses the molecular mechanisms of aging-related changes in liver architecture, which is crucial for understanding the root causes of aging and potential interventions.

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