Aging induces sarcopenia by disrupting the crosstalk between the skeletal muscle microenvironment and myofibers.

Ning Wang, Aojie Zheng, Youzhen Yan, Tailai He, Xuan Wu, Menglin Xian, Jingyuan Luo, Changjun Li, Jie Wei, Yilun Wang, Chao Zeng, Guanghua Lei

Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China; Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China; Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University, Changsha, China.Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China; Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China; Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University, Changsha, China. · pubmed

Paper

Abstract

Sarcopenia is a degenerative muscular disease associated with aging, characterized by a reduction in muscle mass and strength. This disease poses a significant global health challenge, owing to its high prevalence and association with adverse outcomes such as increased frailty, impaired physical function, and elevated mortality risk. A deeper understanding of its underlying mechanisms is urgently warranted for the development of effective therapeutic interventions.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Aging disrupts the crosstalk between the skeletal muscle microenvironment and myofibers, leading to sarcopenia. This paper is relevant as it addresses the mechanisms underlying a significant age-related condition, potentially informing therapeutic strategies that target the root causes of aging-related muscle degeneration.

Author of this paper? Send a correction.