Energetic cost of biosynthesis modulates the growth-longevity tradeoff in mice: Quantitative insights into four lifespan-altering manipulations.

Chen Hou, Fahimeh Taheri

Biology Department, Missouri University of Science and Technology, Rolla, MO 65409, United States. Electronic address: [email protected] Department, Missouri University of Science and Technology, Rolla, MO 65409, United States. Electronic address: [email protected]. · pubmed

Paper

Abstract

Life history theory proposes a tradeoff between growth rate and lifespan, typically explained by the allocation of limited energy resources between somatic growth and maintenance. However, this explanation does not give a complete picture of the energy tradeoff. This study investigates two energy allocation mechanisms that influence growth and longevity simultaneously: the redirection of metabolic energy from growth to maintenance under energy limitation, and increased energy investment in biosynthesis, enhancing bio-tissue quality and stress resistance but also slowing growth. By analyzing empirical data from laboratory mice subjected to diet restriction (DR), dwarfism through genetic manipulations (Dwarf), rapamycin treatment (Rap), and growth hormone transgenics (Super), we quantify changes in growth rate, metabolic rate, and biosynthesis energy costs (E

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Research summary

The paper claims that the energetic cost of biosynthesis influences the growth-longevity tradeoff in mice. This research is relevant as it explores mechanisms that directly affect longevity and aging by examining energy allocation between growth and maintenance, which are critical factors in understanding lifespan extension.

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