Environmental factors capable of broadly interfering with nutritional lifespan extension paradigms.

Sainan Li, Nicole L Stuhr, Fasih Ahsan, Yifei Zhou, Armen Yerevanian, Jen Rotti, Khoi Dao, Mohit Jain, Alexander A Soukas

Department of Medicine, Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.Department of Medicine, Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. · pubmed

Paper

Abstract

Despite being principally prescribed to treat type 2 diabetes, biguanides, especially metformin and phenformin, have been shown to extend lifespan and healthspan in preclinical models. Although there have been conflicting results in studies involving rodents and humans, consistent evidence indicates metformin and phenformin's ability to significantly extend lifespan in

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the effects of biguanides, particularly metformin and phenformin, on lifespan extension in preclinical models. This research is relevant as it explores potential interventions that could address the biological mechanisms of aging and lifespan extension.

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