Lamin A/C Expression in Hematopoietic Cells Declines During Human Aging and Constrains Atherosclerosis in Mice.

Marta Amorós-Pérez, Alberto Del Monte-Monge, Pilar Gonzalo, María J Andrés-Manzano, Cristina Rius, Víctor Fanjul, Cristina González-Gómez, Guillermo Moreno, Alberto Benguría, Ana Dopazo, Fátima Sánchez-Cabo, Carlos Torroja, Fernando Martínez de Benito, Bianca Calì, Pablo Vargas, Carlos Silvestre-Roig, José M González-Granado, Héctor Bueno, José J Fuster, Vicente Andrés

Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.B., A.D., F.S.-C., C.T., F.M.d.B., H.B., J.J.F., V.A.).Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.B., A.D., F.S.-C., C.T., F.M.d.B., H.B., J.J.F., V.A.). · pubmed

Paper

Abstract

Aging is the primary risk factor for atherosclerosis, a degenerative process regulated by immune cells and the leading cause of death worldwide. Previous studies on premature aging syndromes have linked atherosclerosis to defects in A-type lamins, key nuclear envelope components. However, whether these defects influence atherosclerosis during normal aging remains unexplored. Here, we examined how aging affects lamin A/C expression in circulating leukocytes and investigated the impact of manipulating their expression in hematopoietic cells on their function and atherosclerosis progression.

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Research summary

The paper claims that the decline of lamin A/C expression in hematopoietic cells during aging contributes to atherosclerosis progression. This research is relevant as it explores a potential mechanism linking aging to atherosclerosis, addressing a root cause of age-related diseases rather than merely treating symptoms.

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