Nanosecond pulsed electric field applications rejuvenate aging endothelial cells by rescuing mitochondrial-to-nuclear retrograde communication.

Meifang Yin, Jie Xiao, Guangtao Huang, Huanyu Xie, Hongwei Liu, Jianqiang Yuan, Xiaofang Liu, Anna Chiarini, Ubaldo Armato, Ilaria Dal Prà, Shumaila Ijaz, Naziat Begum, Lingyun Wang, Jun Wu

Department of Burn and Plastic Surgery, Medical Innovation Technology Transformation Center, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China.Department of Burn and Plastic Surgery, Medical Innovation Technology Transformation Center, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China. · pubmed

Paper

Abstract

Endothelial cell aging is strongly associated with mitochondrial dysfunction, particularly the disruption of mitochondrial-nuclear retrograde communication (MNRC), which is essential for sustaining cellular homeostasis and regulating crucial cellular processes. Nanosecond pulsed electric fields (nsPEF) were shown to exert biological effects by targeting mitochondria. However, the nsPEF regulation of MNRC is still unclear.

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Research summary

Nanosecond pulsed electric fields can rejuvenate aging endothelial cells by improving mitochondrial-to-nuclear retrograde communication. The study addresses a mechanism related to mitochondrial dysfunction, which is a key factor in the aging process and has implications for cellular rejuvenation and longevity.

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