Aging reprograms the rhythmic transcriptome in the retina.

Zhijie Wang, Lifeng Chen, Lin Li, Mengai Wu, Bin Zheng, YuanYuan Fan

Department of Retina Center, Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Hangzhou, China; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China; Eye Research Center, Hangzhou Institute of Medicine, Chinese Academy of Sciences, Eye Hospital, Wenzhou Medical University, Hangzhou, China.Department of Retina Center, Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Hangzhou, China; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China; Eye Research Center, Hangzhou Institute of Medicine, Chinese Academy of Sciences, Eye Hospital, Wenzhou Medical University, Hangzhou, China. · pubmed

Paper

Abstract

Aging is a significant risk factor for various retinal degenerative diseases. However, its impact on diurnal transcriptional profile of the retina remains largely unexplored. Addressing this knowledge gap is crucial given the rising prevalence of age-related retinal diseases.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that aging alters the rhythmic transcriptional profile in the retina. This research is relevant as it explores the underlying mechanisms of aging and their impact on retinal health, potentially contributing to our understanding of age-related diseases.

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