A reference model of circulating hematopoietic stem cells across the lifespan with applications to diagnostics.

N Furer, N Rappoport, O Milman, S Tavor, A Lifshitz, A Bercovich, O Ben-Kiki, A Danin, M Kedmi, Z Shipony, D Lipson, E Meiri, G Yanai, S Shapira, N Arber, S Berdichevsky, J Tyner, S Joshi, D Landau, S Ganesan, N Dusaj, P Chamely, N Kaushansky, N Chapal-Ilani, R Shamir, A Tanay, L Shlush

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. · pubmed

Paper

Abstract

With aging, deviation of human blood counts from their normal range accompanies the transition from health to disease. Hematopoietic stem and progenitor cells (HSPCs) deliver life-long multi-lineage output, but their variation across healthy humans with aging, and their diagnostic utility, haven't been characterized in depth thus far. To address this, we introduced an HSPC reference model using single-cell RNA profiling of circulating CD34

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Research summary

The paper introduces a reference model of circulating hematopoietic stem cells (HSPCs) across the lifespan to characterize their variation with aging and potential diagnostic applications. This research is relevant as it addresses the biological underpinnings of aging by exploring the role of HSPCs in health and disease, which could contribute to understanding age-related changes and their implications for longevity.

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