Long-term Safety Pharmacology and Musculoskeletal Changes of HMGB1 Box A Gene Therapy in Middle-aged Monkeys.

Sukanya Jaroenporn, Tayanee Chundee, Sakawdaurn Yasom, Lalitta Suriya-Arunroj, Motee Chimngam, Nutchanat Suttisan, Suchinda Malaivijitnond, Apiwat Mutirangura

Department of Biology, Faculty of Science, Chulalongkorn University, Bangkok, Thailand; [email protected] of Biology, Faculty of Science, Chulalongkorn University, Bangkok, Thailand; [email protected]. · pubmed

Paper

Abstract

HMGB1 Box A gene therapy is a promising therapeutic approach for age-associated diseases, based on evidence from

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Research summary

The paper investigates the long-term safety and musculoskeletal changes associated with HMGB1 Box A gene therapy in middle-aged monkeys. This research is relevant as it explores a gene therapy approach that may address underlying mechanisms of aging and age-related diseases rather than merely treating symptoms.

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