NeuroD2 Modulates Hippocampal Neuronal Organization and Axon Guidance During Aging.

Merve Beker, Busenur Bolat, Bahar Sarikamis Johnson, Nilufer Ercin, Rabia Kalkan Cakmak, Sare B Kaya, Nail Besli, Ulkan Celik, Mustafa C Beker

Department of Medical Biology, International School of Medicine, University of Health Sciences Turkiye, Istanbul, Turkiye; [email protected]. · pubmed

Paper

Abstract

Biological aging refers to the progressive deterioration of an organism's functions due to accumulated cellular and molecular damage. NeuroD2, a critical transcription factor, plays a crucial role in neuronal development and synaptic maturation. This study investigates the role of NeuroD2 in hippocampal neuron organization, focusing on hilar mossy cells during aging, and employs bioinformatics to identify NeuroD2 targets linked to cellular aging.

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Research summary

NeuroD2 modulates hippocampal neuronal organization and axon guidance during aging. The study addresses the role of a transcription factor in neuronal development and aging, which is pertinent to understanding the mechanisms of biological aging.

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