Combination of biological aging and genetic risk helps identify at-risk population of thoracic aortic aneurysms insight from a prospective cohort study of UK Biobank.
Abstract
Both age and genetic risk are associated with risk of thoracic aortic aneurysms (TAA). This study seeks to explore the association between phenotypic age acceleration (PhenoAgeAccel), a novel biomarker of aging, and risk of TAA, as well as to conduct risk stratification for TAA based on PhenoAgeAccel and genetic risk.
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Research summary
The study claims that phenotypic age acceleration and genetic risk can be used to identify individuals at risk for thoracic aortic aneurysms. This research is relevant as it explores the intersection of biological aging and genetic predisposition, potentially contributing to understanding age-related diseases and risk stratification in aging populations.
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