Plasma microRNA signatures of aging and their links to health outcomes and mortality: findings from a population-based cohort study.

Lieke M Kuiper, Michelle M J Mens, Julia W Wu, Jaap Goudsmit, Yuan Ma, Liming Liang, Albert Hofman, Trudy Voortman, M Arfan Ikram, Jeroen G J van Rooij, Joyce B J van Meurs, Mohsen Ghanbari

Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands. · pubmed

Paper

Abstract

MicroRNAs are small non-coding RNAs that regulate gene expression post-transcriptionally and show differential expression in various tissues with aging phenotypes. Detectable in circulation, extracellular microRNAs reflect (patho)physiological processes and hold promise as biomarkers for healthy aging and age-related diseases. This study aimed to explore plasma extracellular microRNAs as a biological aging indicator and their associations with health outcomes using population-level data.

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Research summary

The paper claims that plasma microRNA signatures can serve as biomarkers for biological aging and are associated with health outcomes. This research is relevant as it explores potential indicators of biological aging, which could contribute to understanding the root causes of aging and age-related diseases.

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