Enhancing autophagy by redox regulation extends lifespan in Drosophila.

Claudia Lennicke, Ivana Bjedov, Sebastian Grönke, Katja E Menger, Andrew M James, Jorge Iván Castillo-Quan, Lucie A G van Leeuwen, Andrea Foley, Marcela Buricova, Jennifer Adcott, Alex Montoya, Holger B Kramer, Pavel V Shliaha, Angela Logan, Filipe Cabreiro, Michael P Murphy, Linda Partridge, Helena M Cochemé

MRC Laboratory of Medical Sciences (LMS), London, UK.MRC Laboratory of Medical Sciences (LMS), London, UK. · pubmed

Paper

Abstract

Dysregulation of redox homeostasis is implicated in the ageing process and the pathology of age-related diseases. To study redox signalling by H

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Research summary

Enhancing autophagy through redox regulation can extend lifespan in Drosophila. This research addresses the underlying mechanisms of aging by exploring how redox homeostasis and autophagy influence lifespan, which is directly relevant to longevity studies.

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