High-Sensitivity C Reactive Protein Mediates Age-Related Vascular Dysfunction: The Rotterdam Study.

Soroush Mohammadi Jouabadi, Annique Claringbould, A H Jan Danser, Bruno H Stricker, Maryam Kavousi, Anton J M Roks, Fariba Ahmadizar

Vascular medicine and Pharmacology, Department of Internal Medicine, Erasmus MC University Medical center, Rotterdam, the Netherlands. · pubmed

Paper

Abstract

To investigate the role of chronic low-grade systemic inflammation-specifically high-sensitivity C-reactive protein (hsCRP)-in mediating the relationship between aging and vascular dysfunction, and to assess its causal contribution relative to lipid metabolism. We also examined sex-specific mediation to evaluate differences in inflammatory pathways between men and women.

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Research summary

High-sensitivity C-reactive protein mediates the relationship between aging and vascular dysfunction. The study addresses chronic low-grade inflammation as a potential root cause of age-related vascular issues, which is pertinent to understanding aging mechanisms.

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