CD38-Targeting Peptide Vaccine Ameliorates Aging-Associated Phenotypes in Mice.

Shangcheng Yu, Zhiqiang Li, Yuxiang Tang, Yuling Chen, Yingying Ma, Kunlin Du, Zhaoyun Zong, Kangze Feng, Yali Wei, Limeng Chen, Haiteng Deng

MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systematic Biology, State Key Laboratory of Complex, Severe, and Rare Diseases, Tsinghua University, Beijing, China.MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systematic Biology, State Key Laboratory of Complex, Severe, and Rare Diseases, Tsinghua University, Beijing, China. · pubmed

Paper

Abstract

Antiaging vaccines have recently been found to elicit long-term benefits in slowing the aging process. Meanwhile, high CD38 expression in organs is an aging characteristic contributing to a decreased NAD

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Research summary

The paper claims that a CD38-targeting peptide vaccine can ameliorate aging-associated phenotypes in mice. This research addresses a potential intervention targeting a mechanism of aging, specifically the role of CD38 in NAD metabolism, which is relevant to longevity and age-related decline.

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