The Yin and Yang of replicative aging and rejuvenation.

Wei-Han Lin, Aliaksandr Damenikan, Yves Barral

Institute of Biochemistry, Department of Biology, ETH Zürich, Zürich, Switzerland; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan; Biotechnology Center, National Chung Hsing University, Taichung, Taiwan; Doctoral Program in Microbial Genomics, National Chung Hsing University and Academia Sinica, Taiwan.Institute of Biochemistry, Department of Biology, ETH Zürich, Zürich, Switzerland; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan; Biotechnology Center, National Chung Hsing University, Taichung, Taiwan; Doctoral Program in Microbial Genomics, National Chung Hsing University and Academia Sinica, Taiwan. · pubmed

Paper

Abstract

Budding yeast undergoes replicative aging through asymmetric cell divisions. Yeast mother cells progressively age as they generate successive daughter cells, until they ultimately die. However, their daughters are born rejuvenated, that is, most of them recover a full lifespan potential, with little impact of their mothers' age at their birth. In this review, we will discuss recent findings regarding the mechanisms of replicative aging and rejuvenation. Based on these insights, we will also discuss which evolutionary forces may have presided over the emergence of aging in yeast. We suggest that aging and rejuvenation represent two adaptive strategies that each bring their own benefits.

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Research summary

The paper discusses the mechanisms of replicative aging and rejuvenation in budding yeast. This research is relevant as it explores fundamental aspects of aging and rejuvenation, which are critical to understanding the biological processes underlying longevity.

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