Shorter life- and health-span, disturbed insulin-like growth factor signalling in cannabinoid receptor type-1 knockout mice.

A Bilkei-Gorzo

Institute of Molecular Psychiatry, Medical Faculty, University of Bonn, 53125 Bonn, Germany. Electronic address: [email protected] of Molecular Psychiatry, Medical Faculty, University of Bonn, 53125 Bonn, Germany. Electronic address: [email protected]. · pubmed

Paper

Abstract

Cannabinoid receptor type-1 (Cnr1) signalling declines with age, which may contribute to the ageing process, as Cnr1 activity influences several hallmarks of ageing. Indeed, previous studies have shown that mice with a genetic deletion of Cnr1 (Cnr1

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Research summary

The paper claims that the genetic deletion of cannabinoid receptor type-1 leads to shorter life- and health-span in mice due to disturbed insulin-like growth factor signaling. This research is relevant as it explores the role of cannabinoid receptor signaling in the aging process, potentially addressing mechanisms that contribute to longevity and age-related decline.

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