Mitochondria-targeted NAD

Xiaolong Shen, Jinquan Hu, Chen Wang, Haoyi Wang, Huajian Zhong, Zifan Zhang, Guoqing Wen, Lei Wang, Minjie Dong, Ye Tian

Department of Orthopedics, Shanghai Changzheng Hospital, Naval Medical University, 415th Fengyang Road, Shanghai 200003, China. · pubmed

Paper

Abstract

Mitochondrial respiratory chain dysfunction-induced chondrocyte senescence is a key contributor to the progression of osteoarthritis (OA), yet effective strategies for restoring mitochondrial respiratory homeostasis remain elusive. Herein, we develop a charge-guided micro/nano interpenetrating network hydrogel that targets cartilage and delivers a mitochondria-directed MnO

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Research summary

The paper claims to develop a hydrogel that targets mitochondria to restore respiratory function in chondrocytes. This research is relevant as it addresses mitochondrial dysfunction, a root cause of aging and age-related diseases like osteoarthritis.

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