Dendrobium officinale extract alleviates aging-induced kidney injury by inhibiting oxidative stress via the PI3K/Akt/Nrf2/HO-1 pathway.

Bingjie Ren, Mengmeng Wang, Danli Hao, Zhimin Wang, Liping Dai

Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, University of Chinese Medicine, Henan, Henan Province, 450046, China. Electronic address: [email protected]. · pubmed

Paper

Abstract

Dendrobium officinale Kimura et Migo (D. officinale), a staple in Traditional Chinese Medicine, has been utilized for centuries and is renowned for its properties in nourishing yin, tonifying the kidneys, and promoting fluid production to benefit the stomach. In recent years, modern pharmacological studies have substantiated its potential in anti-aging and renal protection, highlighting its therapeutic relevance in both traditional and contemporary contexts.

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Research summary

Dendrobium officinale extract mitigates aging-induced kidney injury by targeting oxidative stress through the PI3K/Akt/Nrf2/HO-1 pathway. This research addresses a mechanism related to aging and its impact on kidney function, which is relevant to the broader context of age-related diseases.

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