Delphinidin attenuates cognitive deficits and pathology of Alzheimer's disease by preventing microglial senescence via AMPK/SIRT1 pathway.

Ying Liu, Ting Hong, Mingxuan Lv, Xiaoyu Guo, Panpan Zhang, Aijuan Yan, Wenshi Wei

Department of Neurology, Huadong Hospital Affiliated to Fudan University, Shanghai, 200040, China.Department of Neurology, Huadong Hospital Affiliated to Fudan University, Shanghai, 200040, China. · pubmed

Paper

Abstract

Emerging evidence suggests that senescent microglia play a role in β-amyloid (Aβ) pathology and neuroinflammation in Alzheimer's disease (AD). Targeting senescent cells with naturally derived compounds exhibiting minimal cytotoxicity represents a promising therapeutic strategy.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Delphinidin prevents microglial senescence via the AMPK/SIRT1 pathway, potentially mitigating cognitive deficits in Alzheimer's disease. The paper addresses the role of senescent cells in neurodegeneration, which is a critical aspect of aging and longevity research.

Author of this paper? Send a correction.