Skeletal Muscle Quantity Versus Quality in Heart Failure: Exercise Intolerance and Outcomes in Older Patients With HFpEF Are Related to Abnormal Skeletal Muscle Metabolism Rather Than Age-Related Skeletal Muscle Loss.

Sabra C Lewsey, T Jake Samuel, Michael Schär, Joevin Sourdon, Joseph R Goldenberg, Lisa R Yanek, Shenghan Lai, Angela M Steinberg, Paul A Bottomley, Gary Gerstenblith, Robert G Weiss

Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD. (S.C.L., T.J.S., J.R.G., A.M.S., G.G., R.G.W.).Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD. (S.C.L., T.J.S., J.R.G., A.M.S., G.G., R.G.W.). · pubmed

Paper

Abstract

Heart failure with preserved ejection fraction (HFpEF) is a systemic process with contributions from peripheral factors, including skeletal muscle (SM). Age-associated SM loss and impaired energy metabolism occur without heart failure, but the relative importance of changes in SM quantity versus metabolic quality in patients with HFpEF for exercise intolerance (EI) or outcomes has not been studied. We hypothesized that EI and subsequent clinical outcomes across the adult lifespan in patients with HFpEF are related to impaired SM energy metabolism rather than age-associated SM loss.

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Research summary

The paper claims that exercise intolerance and outcomes in older patients with HFpEF are more closely related to impaired skeletal muscle energy metabolism than to age-related muscle loss. This research is relevant as it explores the underlying metabolic mechanisms in skeletal muscle that contribute to exercise intolerance in heart failure, which is a significant aspect of aging and age-related diseases.

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