Ovarian aging at single-cell resolution: Current paradigms and perspectives.

Junzhi Liang, Shurui Gai, Xinni Na, Jia Hu, Zhongyu Zhao, Duo Zi, Zhijing Na, Wenyan Gao, Fangfang Bi, Da Li

Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China. · pubmed

Paper

Abstract

Ovarian failure is a key event in female reproductive aging, resulting in the depletion of follicular reserve and a decline in fertility. In addition, it triggers systemic pathological changes, including osteoporosis and cardiovascular disease, due to decreased estrogen levels. Despite extensive study, mapping senescent ovarian cells is challenging due to the multicellular composition and heterogeneity of the ovary. In the past decade, single-cell resolution technologies have provided new insights into ovarian aging by enabling the molecular characterization of individual cells. Here, we comprehensively review the application of these technologies in delaying ovarian aging and promoting reproductive health. We summarize their value in uncovering cell-type-specific mechanisms and their potential uses in the research of ovarian aging, ultimately deepening our understanding of its pathogenesis and molecular basis.

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Research summary

The paper reviews the application of single-cell resolution technologies to understand ovarian aging and its implications for reproductive health. The focus on understanding the mechanisms of ovarian aging contributes to the broader field of aging research by addressing the biological processes underlying reproductive decline and associated age-related diseases.

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