Effect of aerobic or resistance exercise, or both on insulin secretion, ciliary neurotrophic factor, and insulin-like growth factor-1 in dieting older adults with obesity.

Georgia Colleluori, Viola Viola, Siresha Bathina, Reina Armamento-Villareal, Clifford Qualls, Antonio Giordano, Dennis T Villareal

Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona 60126, Italy.Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona 60126, Italy. · pubmed

Paper

Abstract

Obesity exacerbates age-related changes in metabolic and physical function. The effect of distinct exercise modalities combined with diet-induced weight loss on insulin secretion in older adults with obesity and frailty is unknown, and the potential mediators of the metabolic and functional improvements induced by lifestyle therapy still need to be identified. We aimed to assess the effects of various exercise therapies coupled with diet-induced weight loss on insulin secretion and sensitivity and on the levels of circulating Ciliary Neurotrophic Factor (CNTF), its receptor (CNTFRα), and Insulin-like Growth Factor-1 (IGF-1) in older adults with both obesity and frailty.

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Research summary

The paper claims that distinct exercise modalities combined with diet-induced weight loss can improve insulin secretion and levels of specific factors in older adults with obesity and frailty. This research addresses metabolic health in aging populations, which is crucial for understanding and potentially mitigating age-related decline.

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