Relationships between measures of neurovascular integrity and fluid transport in aging: a multi-modal neuroimaging study.

Ella Rowsthorn, Lachlan Cribb, Benjamin Sinclair, William Pham, Trevor T-J Chong, Stephanie Yiallourou, Marina Cavuoto, Lucy Vivash, Terence J O'Brien, Xingfeng Shao, Danny J J Wang, Meng Law, Matthew P Pase, Ian H Harding

Department of Neuroscience, School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia.Department of Neuroscience, School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia. · pubmed

Paper

Abstract

Fluid transport in the neurovascular unit is essential for maintaining brain health through nutrient delivery and waste clearance. However, these systems are complex and the inter-dependencies between elements of these systems and how they may change through aging is not well understood. MRI outcomes provide insight into the underlying biological mechanisms of these systems in vivo, including water exchange rate through the neurovascular unit (BBB k

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Research summary

The paper claims to investigate the relationships between neurovascular integrity and fluid transport in the aging brain. This research is relevant as it explores underlying biological mechanisms that may contribute to aging and age-related cognitive decline, potentially addressing root causes rather than just symptoms.

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