Global m6A RNA and whole 5mC DNA methylation specifically contribute to cell replicative and premature senescence induced by extrinsic oxidative stress.

Chenyu Zhu, Tingting Huang, Jiaqi Fu, Min Li, Luyi Tan, Xinyu Zhang, Wenli Cheng, Caiyun Lai, Zhangying Wang, Wenji Zhang, Wenjuan Zhang

Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, Guangdong, China.Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, Guangdong, China. · pubmed

Paper

Abstract

Hydrogen peroxide (H

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Research summary

The paper claims that global m6A RNA and whole 5mC DNA methylation contribute to cell replicative and premature senescence induced by oxidative stress. This research is relevant as it explores molecular mechanisms that may underlie aging processes and cellular senescence, which are critical factors in longevity and age-related diseases.

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