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RESEARCH PAPER / 2025-06-16
The purinergic receptor P2rx7 mediated ATP sensing is required to prevent bone aging by directing mitochondrial fitness of MSCs.
Zimeng Zhuang, Chunshan Han, Meilian Cai, Mingzhao Li, Shuai Lin, Liujing Chen, Zilu Zhu, Han Zhang, Chenyang Xing, Bing Han, Ruili Yang
Department of Orthodontics, Peking University School and Hospital of Stomatology, Haidian District, Beijing 100081, PR China; National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Haidian District, Beijing 100081, PR China; Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Haidian District, Beijing 100081, PR China.Department of Orthodontics, Peking University School and Hospital of Stomatology, Haidian District, Beijing 100081, PR China; National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Haidian District, Beijing 100081, PR China; Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Haidian District, Beijing 100081, PR China. · pubmed
Abstract
Bone aging, displays osteoporosis and impaired bone formation, intricately linked to the metabolic alteration of mesenchymal stem cells (MSCs). However, the precise mechanisms underlying this relationship remain unclear.
The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.
Research summary
The paper claims that purinergic receptor P2rx7 mediated ATP sensing is essential for maintaining mitochondrial fitness in mesenchymal stem cells to prevent bone aging. This research addresses a mechanism related to the aging process and its impact on stem cell function, which is relevant to understanding and potentially mitigating age-related decline in bone health.
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