Bioinformatics and experiments reveal the hub genes of age-related hearing loss and the mechanism of PLK1 silencing in the protection of aging cochlear hair cells.

Wenting Liu, Bin Ye, Haiyan Cai, Yingying Zou, Yuhai Zou

Department of Otorhinolaryngology, Guangzhou First People's Hospital, Guangzhou, Guangdong, China.Department of Otorhinolaryngology, Guangzhou First People's Hospital, Guangzhou, Guangdong, China. · pubmed

Paper

Abstract

We aim to identify the hub genes and explore molecular mechanisms underlying age-related hearing loss (ARHL) through multi-omics approaches and experimental validation.

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Research summary

The paper identifies hub genes associated with age-related hearing loss and explores the protective mechanisms of PLK1 silencing in cochlear hair cells. This research is relevant as it addresses a specific aspect of aging and seeks to understand underlying mechanisms that could contribute to longevity by protecting sensory cells from age-related degeneration.

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