Signs of Premature Kidney Aging in Mice With Error-Prone Protein Synthesis.

Laurine Lang, Rocío Fuente, José Manuel López, Eva-María Pastor-Arroyo, Petra Seebeck, Dimitri Shcherbakov, Erik Böttger, Lorraine Brennan, Carsten A Wagner, Isabel Rubio-Aliaga

Institute of Physiology, University of Zurich, Zurich, Switzerland. · pubmed

Paper

Abstract

Chronic kidney disease (CKD) is more prevalent with increasing age. The incidence of CKD is rising due to the widespread nature of its risk factors, hypertension and diabetes, and because aging causes a gradual decline in kidney function. This decline is a consequence of structural, molecular, and metabolic changes occurring in aging kidneys. Understanding the mechanisms that accelerate kidney aging may help manage CKD and promote healthy aging. Recently, it has been shown that protein translation errors accelerate aging in mammals. Mice heterozygous for the ribosomal ambiguity mutation Rps9

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Research summary

The paper claims that error-prone protein synthesis accelerates kidney aging in mice. This research is relevant as it explores mechanisms that may contribute to the aging process and chronic kidney disease, potentially leading to strategies for promoting healthy aging and managing age-related decline in kidney function.

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