Combination of Pilose Antler Extract and Hydroxytyrosol Enhances Bone Mineral Density in Both Animals and Postmenopausal Women.

Abstract

Osteoporosis, characterized by reduced bone mineral density (BMD) and impaired bone microarchitecture, imposes a significant global health and economic burden, particularly on postmenopausal women. This study investigated the efficacy of a novel supplement that combines pilose antler extract and hydroxytyrosol (Ruiling capsule) in improving bone health in animal and human trials. In an osteoporotic rat model, Ruiling supplementation significantly increased BMD and bone calcium content, particularly at medium doses, surpassing untreated controls and restoring values to levels comparable with non-osteoporotic rats. In a parallel randomized, double-blind, placebo-controlled clinical trial, postmenopausal women who received Ruiling capsules for 32 weeks showed marked improvements in lumbar-spine and femoral-neck BMD, bone turnover markers, antioxidant enzyme activities, and reduced low back pain compared to the placebo group. No adverse effects were observed, suggesting that modulation of oxidative stress may underpin the bone-protective effects. These findings highlight the potential of combining pilose antler extract and hydroxytyrosol to address the multifactorial osteoporosis pathogenesis. The Ruiling capsule represents a safe, non-pharmacological intervention that offers both structural and functional benefits and could contribute to the long-term management of osteoporosis in aging populations.