Three-Dimensional Bioprinted Scaffolds Loaded with Multifunctional Magnesium-Based Metal-Organic Frameworks Improve the Senescence Microenvironment Prompting Aged Bone Defect Repair.

Xin Sun, Xiang Xu, Xue Zhao, Jie Ma, Tianchang Wang, Xiaokun Yue, Xueheng Sun, Xiaojun Li, Xiaojiang Sun, Weijiao Zhang, Kai Zhang, Deteng Zhang, Xin Zhao, Wenjie Jin, Jinwu Wang

Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai 200011, China.Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai 200011, China. · pubmed

Paper

Abstract

Age-related bone defects cause disability and mortality in older individuals. During bone repair in older individuals, high oxidative stress and excessive inflammation in the senescent microenvironment (SME) lead to bone marrow mesenchymal stem cell (BMSC) senescence, thereby affecting bone regeneration. In this study, we prepared multifunctional magnesium (Mg) and cerium (Ce) ion-based metal-organic frameworks (MOFs) using a hydrothermal method and constructed a three-dimensional (3D) bioprinted scaffold to effectively scavenge reactive oxygen species (ROS) and sustainably release Mg

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Research summary

The paper claims that 3D bioprinted scaffolds loaded with magnesium-based metal-organic frameworks can improve the senescence microenvironment and enhance bone defect repair in aged individuals. This research addresses the senescence microenvironment, which is a root cause of aging-related bone repair issues, thus contributing to the understanding of aging and potential interventions.

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