Exercise mitigates liver senescence but does not outmatch dietary restriction in obesity-related MASLD.

Angeliki Katsarou, Grigorios Papadopoulos, Ioannis I Moustakas, Argyro Papadopetraki, Athanasios Moustogiannis, Aigli-Ioanna Legaki, Eirini Giannousi, George Agrogiannis, Pavlos Pantelis, Dimitris Veroutis, Konstantinos Evangelou, Athanassios Kotsinas, Vassilis G Gorgoulis, Anastassios Philippou, Michael Koutsilieris, Antonios Chatzigeorgiou

Department of Physiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. · pubmed

Paper

Abstract

The present study aims at deciphering the individual or combined benefits of aerobic exercise and dietary restriction on liver senescence, a state characterized by cell cycle arrest and simultaneous resistance to apoptosis, which is considered an established hallmark of metabolic dysfunction-associated steatotic liver disease (MASLD).

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Research summary

Exercise can mitigate liver senescence, but dietary restriction is more effective in addressing obesity-related MASLD. The study addresses liver senescence, a hallmark of aging, and explores interventions that could potentially influence longevity and age-related metabolic dysfunction.

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