Impact of sarcopenia and obesity on skeletal muscle size, gene expression, and mitochondrial function.

Hector G Paez, Christopher R Pitzer, Jessica L Halle, Peter J Ferrandi, James A Carson, Junaith S Mohamed, Stephen E Alway

Department of Physiology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.Department of Physiology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, 38163, USA. · pubmed

Paper

Abstract

Skeletal muscle is a primary tissue of dysfunction during both aging and obesity. Recently, the coincidence of obesity and aging has gained attention due to the intersection of the obesity epidemic with an aging demographic. Both aging and obesity are associated with marked defects in skeletal muscle metabolic health. Despite these findings, we have a poor understanding of how obesity and aging may interact to impact skeletal muscle mass and metabolic health. Therefore, we investigated the impact of high-fat diet (HFD)-induced obesity on skeletal muscle mass, mitochondrial function, transcriptomics, and whole-body metabolism in young and aged mice. We observed main effects of diet and age on several measures of whole-body metabolic function (VO

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Research summary

The paper investigates the effects of high-fat diet-induced obesity on skeletal muscle mass and metabolic health in the context of aging. This research is relevant as it addresses the interaction between obesity and aging, which are both critical factors in the decline of metabolic health and longevity.

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