Telomere attrition alters extracellular vesicles conferring adverse impacts on neuronal viability and inflammatory response.

Yi Gong, Yunong Wang, Francheska Delgado-Peraza, Carlos Nogueras-Ortiz, Nicole Noren Hooten, Deborah L Croteau, Mithlesh Temre, Abigail E Molnar, Monica Bodogai, Ainslee Zou, Kotb Abdelmohsen, Wei Zhu, Yongqing Zhang, Myriam Gorospe, Nan-Ping Weng, Michele K Evans, Dimitrios Kapogiannis, Yie Liu

Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA.Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA. · pubmed

Paper

Abstract

Telomere shortening is a hallmark of aging associated with various diseases, yet its impact on extracellular vesicles (EVs) remains poorly understood. We investigated EV abundance, size, cargo content, and functional implications in a human aging cohort and the telomerase reverse transcriptase null (

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Research summary

Telomere attrition affects the properties of extracellular vesicles, which in turn impact neuronal viability and inflammatory responses. This research addresses a fundamental aspect of aging by exploring how telomere shortening may influence cellular communication and health, potentially linking it to age-related diseases.

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