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RESEARCH PAPER / 2025-06-12

The efficacy and safety of fecal microbiota transplantation in the treatment of sarcopenia: a retrospective study.

Bo Yang, Xinhui Li, Jiahui Wang, Yue Xu, Le Wang, Zhifeng Wu, Di Zhao, Long Huang, Ning Li, Qiyi Chen, Zhongchen Liu

School of Medicine, Tongji University, Shanghai, China.School of Medicine, Tongji University, Shanghai, China. · pubmed

Abstract

Sarcopenia, a prevalent geriatric syndrome, is influenced by factors such as inflammation, immune deficiency, and oxidative stress. In elderly individuals, alterations in the microbiome, including reduced biodiversity and functional changes, significantly contribute to the progression of the disease. Targeting the gut-muscle axis has emerged as a promising therapeutic strategy to mitigate age-related muscle atrophy and dysfunction.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that fecal microbiota transplantation can improve sarcopenia in elderly individuals. The study addresses the gut-muscle axis, which is a potential root cause of age-related muscle decline, making it relevant to longevity research.

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