A heteropolysaccharide from Hypsizygus ulmarius fruit bodies attenuates D-galactose-induced cognitive decline by enhancing mitochondrial function and improving antioxidant activity in mice.

Sudha Govindan, Jayasakthi Shanmugam, Devaki Unni, Amritha Sukumaran, Prasanna Ramani

Department of Biochemistry, Kongunadu Arts and Science College, Coimbatore 641029, Tamil Nadu, India. Electronic address: [email protected] of Biochemistry, Kongunadu Arts and Science College, Coimbatore 641029, Tamil Nadu, India. Electronic address: [email protected]. · pubmed

Paper

Abstract

The study aimed to examine the antioxidant properties in vitro and the in vivo D-galactose-induced oxidative damage model from the fruiting bodies of Hypsizygus ulmarius Polysaccharide (HUP), which have an average molecular weight of 2.076 × 10

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Research summary

The paper claims that a heteropolysaccharide from Hypsizygus ulmarius can attenuate cognitive decline by enhancing mitochondrial function and improving antioxidant activity. This research addresses mechanisms related to oxidative stress and mitochondrial function, which are important factors in the aging process and age-related cognitive decline.

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